Saturday, March 13, 2010

11 March - CML presenting as priapism

Forgot to include this one last week.  The case was a young male who presented to hospital with priapism.  He had significant leukocytosis on evaluation and was ultimately determined to have CML.  This is an uncommon but not rare clinical presentation in adults with leukemia.  CML treatment has been revolutionized by the introduction of imatinib, a specific inhibitor tyrosine kinase.

Review this disease for boards - everything from the blood smear to the BCR-ABL tyrosine kinase to the Philadelphia chromosome.

For a good reference on blood smears that you can use in teaching, see the American Society of Hematology Image Bank.  Easily searchable database of pretty much any blood smear you could ever want.

For student teaching, they also have these interactive teaching cases designed for medical students.

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