Todays case was a 60 y/o patient with a 9 year history of hemipareisis from a prior hemorrhagic stroke. He was admitted with acute onset RLE pain and swelling and found to have an acute DVT. His D-dimer test was positive and a doppler US revealed a partially occlusive distal thrombus.
Review this Annals In The Clinic article about DVT management. Also has some slidesets that can be used for student teaching.
Whe establishing your pretest probability to determine diagnostic testing - know that there are different Well's criteria for DVT and Well's criteria for PE.
Regarding testing for thrombophilia - there are no clinical trials to support this practice according to a recent Cochrane review of the topic. This extensive review in the American Journal of Medicine contradicts the MKSAP answer from today, in that it proposes that there are very few indications for thrombophilia testing, and there is little evidence to back up the effectiveness of testing in these circumstances to prevent clinical events.
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